Research

My research spans a broad range of topics and disciplines, from chemistry to materials science engineering and biomedical engineering. My research has been focused on better understanding and improving both human and environmental health.

Hydrogel formulations for sustained-release of broadly neutralizing antibodies

Jons, C. K.; Kasse, C. M.; Mayer, B. T.; Hyrien, O.; Sen, S., Meany, E. L.; d'Aquino, A. I.; Ganesh, P.; Eckman, N.; Dong, C.; Yan, J.; Nguyen, L. T.; Doulames, V. M.; Song, Y. E.; Saouaf, O. M.; Williams, C. M.; Williams, S. C.; Paredes, J.; Raghavan, R.; Palomares, M.; Appel, E. A.

Journal of Controlled Release, 2025

Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight

d’Aquino, A. I.; Dong, C.; Nguyen, L. T.; Yan, J.; Jons, C. K.; Saouaf, O. M.; Song, Y. E.; Eckman, N.; Kapasi, S.; Williams, C. M.; Doulames, V.; Sen, S.; Manna, M. K.; Alakesh, A.; Lu, K.; Hall, I.; Appel, E. A.

BioRxiv, 2025

Water-Enhancing Gels Exhibiting Heat-Activated Formation of Silica Aerogels for Protection of Critical Infrastructure During Catastrophic Wildfire

Dong, C.; d'Aquino, A. I.; Sen, S.; Hall, I. A.; Yu, A. C.; Crane, G. B.; Acosta, J. D.; Appel, E. A.

Advanced Materials, 2024

Biomimetic Non-Ergodic Aging by Dynamic-To-Covalent Transitions in Physical Hydrogels

Sen, S.; Dong, C.; d’Aquino, A.I.; Yu, A.C.; Appel, E.A.

ACS Applied Materials & Interfaces, 2024

Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management

d’Aquino, A. I.; Maikawa, C. L.; Nguyen, L. T.; Lu. K.; Hall, I. A.; Jons, C. K.; Kasse, C. M.; Yan, J.; Prossnitz, A. N.; Chang, E.; Baker, S. W.; Hovgaard, L.; Steensgaard, D. B.; Andersen, H. B.; Simonsen, L.; Appel, E. A.

Cell Reports Medicine, 2023

Polyacrylamide-based hydrogel coatings improve biocompatibility of implanted pump devices

Chan, D.; Maikawa, C. L.; d’Aquino, A. I.; Raghavan, S. S.; Troxell, M. L.; Appel, E. A.

J. Biomed. Mater. Res. Part A., 2023

Injectable Hydrogels for Immune Modulation

Saouaf, O.M.; d’Aquino, A.I.; Grosskopf, A.K; Appel, E.A.

Biomedical Nanotechnology: Methods and Protocols, 2023

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors

Grosskopf, A.K.; Labanieh, L.; Klysz, D.D.; Roth, G.A.; Xu, P.; Adebowale, O.; Gale, E.C.; Jons, C.K.; Klich, J.H.; Yan, J.; Maikawa, C.L.; Correa, S.; Ou, B.S.; d’Aquino, A.I.; Cochran, J.R.; Chaudhuri, O.; Mackall, C.L.*; Appel, E.A.

Science Advances, 2022

Injectable Polymer-Nanoparticle Hydrogel for the Sustained Intravitreal Delivery of Bimatoprost

Meany, E.L.^; Andaya, R.^; Tang, S.; Kasse, C.M.; Fuji, R.N.; Grosskopf, A.K.; d’Aquino, A.I.; Bartoe, J.T.; Ybarra, R.; Shelton, A.; Pederson, Z.; Hu, C.; Leung, D.; Nagapudi, K.; Ubhayakar, S.; Yen, C.W.*; Appel, E.A.

Advanced Therapeutics, 2022

Stable High-Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient

Klich, J.H.^; Kasse, C.M.^; Mann, J.L.; Huang, Y.; d’Aquino, A.I.; Grosskopf, A.K.; Baillet, J.; Fuller, G.G.; Appel, E.A.*

Advanced Therapeutics, 2022

Hydrogel-Based Slow Release of a Receptor-Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS-CoV-2

Gale, E.C.; Powell, A.E.; Roth, G.A.; Ou, B.S.; Meany, E.L.; Grosskopf, A.K.; Adamska, J.; Picece, V.C.T.M.; d’Aquino, A.I.; Pulendran, B.; Kim, P.S.; Appel, E.A.

Advanced Materials, 2021

Metal–organic framework nanoparticles (Advanced Materials, 2018)

Highly-active nickel phosphide hydrotreating catalysts prepared in situ using nickel hypophosphite precursors (Journal of Catalysis, 2016)

Reversible and selective encapsulation of dextromethorphan and β-estradiol using an asymmetric molecular capsule assembled via the weak-link approach (Journal of the American Chemical Society, 2017)

Palladium (II) weak-link approach complexes bearing hemilabile N-heterocyclic carbene–thioether ligands (Inorganic Chemistry, 2017)

Effect of Particle Size on the Deep HDS Properties of Ni2P Catalysts (The Journal of Physical Chemistry C, 2019)

A redox-switchable, allosteric coordination complex (Journal of the American Chemical Society, 2018)

A concerted two-prong approach to the in situ allosteric regulation of bifunctional catalysis (Chemical Science, 2016)

An Allosterically Regulated, Four-State Macrocycle (Inorganic Chemistry, 2018)

Infinite coordination polymer particles composed of stimuli-responsive coordination complex subunits (Chemistry of Materials, 2017)

Multi-State Dynamic Coordination Complexes Interconverted through Counterion-Controlled Phase Transfer (Inorganic chemistry, 2021)

Structurally dynamic crystalline 1D coordination polymers enabled via the Weak-Link Approach (Polyhedron, 2022)

Agent Orange and Narratives of Suffering (WWU Occam’s Razor, 2012)